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This is known as the enterohepatic circulation for the ileal reabsorption of bile salts and bile acids
For example, the CARDINAL study (phase II/III, 20172020, and the FALCON study (phase III, 20192023, are ongoing with patients suffering from Alport syndrome (a hereditary progressive renal disease caused by abnormal type IV collagen) and ADPKD (autosomal dominant polycystic kidney disease), respectively [118,119]
Lenzi, A., Sgr, P., Salacone, P., Paoli, D., Gilio, B., Lombardo, F.,
Acts peripherally, meaning it targets fat cells directly rather than influencing central appetite or hormonal pathways
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