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Future options like orforglipron (non-peptide, expected 2026) may simplify timing

Allergic reactions (extremely rare): Recognize symptoms (rash, difficulty breathing, swelling) Discontinue the peptides immediately Seek emergency medical care if severe Document and report Exclude from further research Unexpected serious adverse events: Clear protocols for recognition and management Access to medical care Documentation and reporting requirements Communication with research oversight bodies Review of protocols if serious events occur Safety Documentation Proper documentation of safety is essential

Metformin Is Associated with a Lower Risk of Atrial Fibrillation and Ventricular Arrhythmias Compared with Sulfonylureas: An Observational Study