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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)

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Previous studies showed contradictory results regarding an increase in peptide levels in FD patients compared to health, but the impact of confounders, as the use of acid suppressive therapy for gastrin, the impact of MMC cycle for motilin, and the accumulation of 5-HT in thrombocytes, was not taken into account ( H

This allows the appetite hormones triggered by Calocurb to work more effectively without being drowned out by histamine-driven symptoms

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