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Theres also a trend of greater benefit in physical functioning, body pain and general health domains with greater weight loss. Benefits with both drugs SURMOUNT-5 was a phase 3b randomized controlled open-label trial in which adults with obesity or overweight with at least one obesity-related comorbidity and at least one unsuccessful dietary attempt to lose weight were randomly assigned to once-weekly injectable semaglutide or tirzepatide for 72 weeks

Behavioral factors create substantial variation in outcomes independent of medication dose

37 Regulation of the IL-23/Th17 pathway is another possible mechanism of the anti-inflammatory effects of GLP-1RAs

Expect Dose Changes: As you lose weight, you will likely need less thyroid hormone