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GHK-CU was first discovered in human plasma and later identified in saliva and urine, which highlighted its role in normal physiological processes related to tissue maintenance and repair

Discussion In the current systematic review and meta-analysis, 10 RCTs were analyzed to evaluate the effectiveness and safety of combination therapy with SGLT-2i and GLP-1RA compared to monotherapy of each individually on the incidence of MACE and hospitalization for heart failure

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