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Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

This balanced control over ECM deposition and degradation is critical for its role in promoting healthy tissue architecture rather than fibrotic scar formation

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Our study addresses an important and practical question: whether GLP-1 receptor agonists appear safe in this population and whether their use is associated with meaningful clinical outcomes such as steroid dependence and hospitalization. The researchers used the TriNetX research network to identify adults with Crohns disease and overweight or obesity who either started a GLP-1 receptor agonist or had no exposure