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41589_2021_915_MOESM14_ESM.mpeg Supplementary Video 12 Representative movie for 100 ns MD simulation of GPX4 K48L with the camera zoomed in for a close-up of the active site

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A whole blood histamine test has been useful in clinical practice however it is not an approved diagnostic test

Signaling proteins directly or indirectly recruited to the phosphorylated docking site include the growth factor receptor-bound protein 2 (Grb2) adaptor, the non-receptor tyrosine kinase Src, Src homology 2 domain-containing (Shc) adaptor protein, the p85 subunit of phosphatidylinositol 3 kinase (PI3K), phospholipase C (PLC), tyrosine phosphatase SHP2, Src homology 2-containing inositol 5-phosphatase 1 (SHIP2), signal transducer and activator of transcription 3 (STAT3) and the multisubstrate docking protein Grb2-associated binding protein (Gab1) [57]