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This creates a larger energy deficit

Although most studies suggest that GLP-1 receptor agonists promote weight loss primarily due to their inhibitory effect on food intake, other central impacts that have been described for native GLP-1 and some GLP-1 receptor agonists in rodents and humans inspire future clinical trials to explore additional mechanisms in the CNS

The practical reality Third-party stability studies suggest that semaglutide (in certain formulations) can maintain reasonable stability at temperatures up to 86 degrees Fahrenheit (30 degrees Celsius) for up to 24 hours

JAMA, 325 (14), 14141425

"Patients Taking Experimental Obesity Drug Lost More Than 50 Pounds, Maker Claims"