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Nat Prod Rep 30(11):14381454

Specifically, it explains why: Antihistamines can significantly reduce skin and respiratory symptoms by blocking histamine receptors Low-histamine diets may lessen symptom severity by reducing overall histamine burden in the body Vitamin C and quercetin can be supportive, as both help stabilize mast cells and improve histamine breakdown, thereby dampening the inflammatory response associated with progesterone hypersensitivity N-Acetyl Cysteine (NAC) supports glutathione production and inflammatory regulation, which may further help reduce the downstream effects of mast cell activation when used alongside antihistamines and dietary strategies

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It is classified by the Food and Drug Administration (FDA) as a dietary supplement when it is sold in oral forms, such as capsules, liquids, or liposomal delivery systems