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p , The amplitude of the change in fluorescence (%F/F 0 ) elicited by GLP-1 (1 M, n = 20 neurons) or GLP-1MK-801 (1 M, n = 38 neurons)

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10 Recently, several clinical trials have shown the potential effects of these medications in not only in glycemic control but also in the improvement of cardiovascular outcomes, weight loss, osteoarthritis, 11 metabolic dysfunctionassociated steatohepatitis (MASH), 12 Parkinsons disease, 13 chronic kidney disease (CKD) 14 and obstructive sleep apnea

In recent years, intestinal-joint axis has become a key frontier field in the research of rheumatoid arthritis (Zaiss et al., 2021)