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BHV-1400 Targets the non-immunosuppressive, selective depletion of circulating galactose-deficient Iga1 in Iga nephropathy, Biohaven Pharmaceuticals, Inc , Poster at the 4th Annual Targeted Protein Degradation Summit Europe, London, United Kingdom, March 19-21, 2024 (2024)

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Consistent with human observations, H2O2 also promoted FOXO4 nuclear translocation in TM3 cells, along with an increase in senescence markers p53, phospho-p53, and p21, while reducing testosterone synthesis-related enzymes like CYP11A1 and CYP17A1