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(2) Creatine (CRE) group 1 (CRE21): 30% w / v solution of 21 mg/kg BW of creatine

A subsequent pilot study (n=12) comparing oral liposomal glutathione (500 mg twice daily for 2 weeks) found increases in GSH levels in whole blood, erythrocytes, and plasma, along with reductions in 8-isoprostane (a marker of oxidative stress) (Buonocore et al., Oxid Med Cell Longev, 2016) [16]

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As a result, with repeated sickling episodes, red cells become dehydrated, dense, and rigid ( Fig