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Our results showed that ethanol exposure for 810 weeks may activate the inflammasome NLRP3, promoting the secretion of the pro-inflammatory factor TNF- in the hippocampus of ethanol-exposed APP/PS1 mice, which is consistent with the results of A depositions and impaired antioxidant capacity

We also theorize that due to the relatively short-half-life of MT-II (approximately 2 hours), once or twice daily dosing may not be sufficient to meet a threshold at which effective neuro-modulation may occur in adult C57BL/6J mice

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