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Semaglutide also affects gastrointestinal motility more broadly, not just gastric emptying

Sustaining fat loss over time by improving metabolic flexibility

How GLP-1 Receptor Agonists Cause Weight Loss By binding to the GLP-1 receptor, GLP-1 RAs mimic the effects of having eaten and released GLP-1

The pain typically increases when you flex your foot upward (dorsiflexion), a clinical sign called Homans sign, though this test is neither sensitive nor specific enough for diagnosis

This dual agonism allows the drug to lower glucose levels and reduce weight, but the side effects reported for Mounjaro are similar to other GLP-1 agonists