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hospitalization required Maintenance of Remission: Immunomodulators (azathioprine, 6-MP, methotrexate) for steroid-dependent or frequently-relapsing disease Biologic monotherapy or combination therapy (biologic + immunomodulator) for moderate-to-severe disease Step-up or top-down approach based on disease severity, patient risk factors, and prior therapy Biologic Therapy Targets: TNF-: Infliximab (IV), adalimumab (SC), certolizumab pegol (SC) IL-12/23: Ustekinumab (IV induction, SC maintenance) Integrin: Vedolizumab (IV) IL-23: Risankizumab (IV induction, SC maintenance) JAK inhibition: Upadacitinib (oral) Surgical Management Surgery is indicated in approximately 7080% of patients with Crohns disease over their lifetime, per StatPearls

Available online: [DOI] [PubMed] [Google Scholar] 18.Manchikanti L., Falco F., Benyamin R., Kaye A., Mark B., Hirsch J

Visceral and liver fat reductions are material over time, alongside improving lipid panels and insulin

Lipotropic injections are generally administered in areas that contain significant subcutaneous fatty tissues, e.g., the arm, thigh, buttocks, or abdomen

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