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However, the natural product T2 , with a replacement of the sulfur atom of T1 by an oxygen atom, shows 713-fold decrease in the inhibitory ability (IC 50 = 378.11 M)

The mechanism of magnesium block of NMDA receptors

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Even at equiactive doses, ligands of different efficacies will be occupying different fractions of receptors and may be initiating different desensitization cascades, further confounding simple interpretation

Lee SJ, Lee KH, Oh HG, Seo HJ, Jeong SJ, Kim CH