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Bioinformatics analysis The software DAVID ( was used to perform enrichment analysis, and the method used was Fishers exact test to perform GO functional significance enrichment analysis on differential proteins

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While all studies adequately ascertained exposure and ensured comparability between outcome groups by controlling for confounders, 42% (n = 5) did not provide adequate sample representativeness and size, and 17% (n = 2) did not report the non-response rate