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Iron exhibits redox activity and engages in the production of intracellular free radicals and lipid peroxides ( via the Fenton reaction, which means reactions of Fe 2+ and peroxides to generate oxygen-centered radicals (Winterbourn, 1995)

According to a narrative review done in 2025, it was originally isolated from human gastric juice by Dr

Beta-2 microglobulin (B2M) served as the endogenous reference gene for normalization

Mol Aspects Med 26:3365 Niles JC, Wishnok JS, Tannenbaum SR (2006) Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation

Inadequate response after 1216 weeks at a therapeutic maintenance dose (typically 1015 mg weekly) justifies reassessment