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In addition, the cells of perfused placentas remain viable and feasible for up to 12 h [20,21]

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Similarly, ascorbic acid may exert antidepressant effects by restoring antioxidant enzyme activity (Moretti et al., 2013), activating the opioid receptor system (particularly the -opioid receptor), inhibiting NMDA receptors, or both (Moretti et al., 2018

This is why patients with neurological involvement are often maintained on a more frequent schedule (every 2 months rather than every 3 months)