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Additionally, pattern recognition receptors like TLR2 and TLR4 on microglia can be chronically stimulated or desensitized by repetitive exposure to microbial MAMPs translocating from the gut, potentially affecting how microglia respond to misfolded proteins (either by over-reacting and causing bystander damage, or by entering a tolerant state that might impair clearance of aggregates) [71, 119]

Castillo, P

Vitamin B12 is a water-soluble vitamin with a molecular weight of 192.4 Daltons that is essential in the body for cell division and DNA synthesis

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B12 is a water soluble vitamin and when given in the injection formula, it usually last a week versus a pill or liquid form that only last a few hours