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they can generate mechanical force via enzyme-driven or physical-driven mechanisms to actively penetrate dense stroma, while enhancing therapeutic efficacy by regulating microenvironmental parameters (e.g., alleviating hypoxia and remodeling immune balance) [274]

In a phase 3 trial, participants taking the highest dose of retatrutide lost an average of 28.7% of their body weight

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Less water in the body = less saliva

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