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Biomolecules 14 , 1558 (2024)

Currently, once-weekly subcutaneous semaglutide 2.4 mg is approved for chronic weight management in adults with obesity, or overweight and with at least one weight-related comorbidity 17 , for reducing CV risk in adults with established cardiovascular disease (CVD) with obesity or overweight 18 , and in adolescents aged 12 years and older 19 , in conjunction with a reduced-calorie diet and increased physical activity plan

Recent clinical studies demonstrate that GLP-1 receptor agonists, including semaglutide, may reduce liver fat accumulation by improving insulin sensitivity and promoting weight loss

These carry specific FDA-approved indications and extensive clinical trial data

However, its important to consult with a healthcare provider before starting any supplementation, as excessive intake can have side effects