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Monitoring For patients on chronic GHK-Cu: Serum copper and zinc at baseline and periodically Liver function tests in patients on long-duration protocols Clinical assessment of any new neurological or hepatic symptoms Standard compounded-peptide quality and sourcing practices Key Takeaways GHK-Cu is a copper-binding peptide with a generally favorable safety profile

The same recommendation applies for dapsone, a sulfone, which also does not need to be withheld

Consistent with the upregulation of ZnT8 observed in human diabetic cells, ZnT8 expression was significantly increased in cells from HFD-fed mice compared with those from ND-fed controls (Supplementary information, Fig