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Biochemical and genetic evidence for the hepatitis B virus replication strategy

SIRT1 also provides feedback regulation along the ROSmitochondrial damageautophagic dysfunction axis, 102,177,178 reducing oxidative accumulation and repairing mitochondrial metabolic alterations, interrupting the oxidative stressinflammationenergy collapse cycle in MASLD

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Additionally, the upregulation of inflammation-related genes, such as IL-6 and TNF-, is associated with the pathological state of depression, suggesting that immune responses play a critical role in its pathogenesis [365, 366]

doi: 10.7554/eLife.10067