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GLP-1R KO can lead to increased appetite, contributing to weight gain.1 GLP-1R is involved in regulating both insulin and glucagon secretion, and its knockout can impair pancreatic function, thereby affecting the balance of these hormones and glucose homeostasis.41,42 GLP-1R is expressed in the cardiovascular system, and its knockout has implications for cardiovascular function.43,44 GLP-1R is present in the CNS, and its absence might contribute to alterations in behavior, mood, or cognitive function.45,46 GLP-1R GLP-1R GPCR , GLP-1

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[DOI] [PubMed] [Google Scholar] 35.Meissner Wassilios G., Remy P., Giordana C., Maltte D., Derkinderen P., Houto J.-L., Anheim M., Benatru I., Boraud T., Brefel-Courbon C., et al

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Precision genetic testing can reveal predispositions in these peptide pathways, helping providers contextualize treatment response variability and adjust strategywhether through formulation choice, dosing schedule, or combination approaches