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Incor-porating machine learning approaches to assess putative environmental risk factors for multiple sclerosis

Introduction Sulfur is an essential element that is incorporated into various cellular metabolites and used for multiple metabolic processes in fungi, including the proteogenic amino acids cysteine (Cys) and methionine (Met), oxidative stress defense [glutathione (GSH) and ergothioneine (EGT)], methylation [ S -adenosylmethionine (SAM)], epipolythiodioxopiperazine (ETP) toxin biosynthesis (e.g., gliotoxin) and iron metabolism (FeS clusters) (Struck et al., 2012