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20 In agreement with the ADA, the American Association of Clinical Endocrinologists (AACE) lists DPP-4 inhibitors as an alternative in patients with an A1C under 7.5% in whom the use of metformin is contraindicated

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Some of the change may be related to shifts in fluid balance or other tissues

[PUBMED Abstract] Hancock BW, Wheatley K, Harris S, et al.: Adjuvant interferon in high-risk melanoma: the AIM HIGH Study--United Kingdom Coordinating Committee on Cancer Research randomized study of adjuvant low-dose extended-duration interferon Alfa-2a in high-risk resected malignant melanoma