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An animal study on gut microbial composition revealed significant -diversity differences between chronic unpredictable mild stress (CUMS) rats and control rats (Meng et al., 2025), which aligns with observational findings (McGuinness et al., 2022)

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Free Radic Biol Med 27:922935 Griffith OW, Mulcahy RT (1999) The enzymes of glutathione synthesis: -glutamylcysteine synthetase

Because people with HIV often experience accelerated aging even when the virus is well controlled, this was a population where we might expect a metabolic intervention to register a measurable signal, so the direction was plausible

Drowsiness or sedation Dry mouth Constipation Dizziness or lightheadedness when standing Sudden discontinuation can cause rebound hypertension, so tapering under medical supervision is essential