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Many patients continue losing weight even after reaching their maintenance dose, because the cumulative metabolic changes deepen over months 56 of treatment

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A small percentage maintain loss through intensive lifestyle modification alone, but research shows fewer than 10-15% sustain clinically significant weight loss without medication long-term

Lean mass does include more than just skeletal muscle, but preserving muscle is essential, particularly in midlife and older adults, where age-related muscle loss (sarcopenia) is already occurring

The liver was dissected, dehydrated in alcohol, and embedded in paraffin according to standard procedures