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Attempts to measure peak concentrations early after oral dosing are usually unsuccessful and compromise the validity of the measurement, because one cannot be certain that absorption is complete

Increase in acetylcholine concentrations in the brain of old rats following treatment with pyrithioxin (Encephabol) Br

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While that may sound destabilizing, it points to a conformational shift in DNA duplex architecture that could facilitate transcription while preventing hardening of the genome that often accompanies age and oxidative stress [37]

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