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Quantitative imaging of glutathione in live cells using a reversible reaction-based ratiometric fluorescent probe

Luban, Naomi L C

For example, the mutant presenilin 1, one of the main causes of familial AD, was found to cause a dysfunction in lysosomal acidification, leading to elevated lysosomal pH values 125 , lysosomal proteolysis injury, and AD-like pathologic alterations 126

Thus, the -glutamyl cycle, apart from explaining the synthesis and degradation of glutathione, may serve as a generator of signals to activate amino acid transport into cells (75)

As discussed elsewhere, the role of IFN-I in tumor biology and immune responses is, per se, dichotomous, promoting cytotoxicity of NK cells and CD8 + T cells in some circumstances but also the suppressive function of Tregs in others [177,178,179]