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Fierce Pharma

The lipophilicity profile (consensus Log Po/w = 1.23) indicated a moderately lipophilic nature, favorable for membrane permeability

some comparisons used semaglutide doses that are no longer the highest available, and no completed head-to-head trial has compared the two medicines at their current highest approved doses

5.3 Acute lung injury Due to the presence of extensive capillary beds in the lungs and the abundance of immune cells in the lung parenchyma, the systemic inflammatory response activated by ECMO renders lung tissue extremely susceptible to acute injury (114, 115)