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In parallel, cystinosin (CTNS) exports lysosomal cystine to the cytosol, linking lysosomal function to cysteine availability and GSH synthesis 141

Thus, NO could modulate muscle atrophy via redox-mediated control of protein synthesis, proteolysis or inflammation and GSH is of fundamental importance to counterbalance high nitrosative stress that whether exacerbated could result in cell death

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Zepbound was fast-tracked due to high demand, but critics argue the approval relied heavily on short-term trials without fully addressing long-term outcomes