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Mitochondrial dysfunction in Parkinsons disease a key disease hallmark with therapeutic potential

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CoQ 10 generated via the mevalonate pathway functions as an endogenous antioxidant, which inhibits ferroptosis by reducing the accumulation of intracellular lipid peroxide [186, 187]

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Oligodendrocytes can metabolically support axons by providing monocarboxylates, classically discussed as lactate, but potentially also pyruvate, to sustain axonal energy demands