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Furthermore, the patient's AUDIT score improved from a high-risk 27 to a 7, representing a clinically significant 20-point reduction

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In another study, rats with diabetic kidney disease (DKD) were treated with a CD38 inhibitor, resulting in increased renal NAD + levels, which in turn decreased mitochondrial oxidative stress 144

Efficacy and safety of topiramate on weight loss: a meta-analysis of randomized controlled trials