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Modifications of the endocannabinoid system by exogenous administration of cannabinoid agonists can disturb normal reproductive processes, possibly through free radical production [316]

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This occurs when MOR-effector coupling is impaired either by irreversible antagonists or chronic drug treatment presumably because low intrinsic-efficacy agonists such as morphine must occupy a greater fraction of the total receptor population to produce a given level of effect, due to lesser receptor reserve (Christie et al., 1987

I do feel as if I am not as fatigued