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The pathological role of amylin in diabetes development has been extensively studied, with elevated amylin levels leading to fibril formation that may contribute to beta cell toxicity and insulin resistance

Studies have shown that IGF1 LR3 can influence fiber type makeup and may promote a shift toward more oxidant fiber types

IGF-DES Potency vs Native IGF-1 Studies using cultured cells confirmed that the biological potencies of IGF-1, IGF-2, and des-(1-3)-IGF-1 correlate inversely with their binding to IGFBP proteins in conditioned media establishing that des-(1-3)-IGF-1s enhanced in vivo and in vitro potency is a direct consequence of reduced IGFBP sequestration rather than greater intrinsic receptor affinity

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