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SIRT1 stimulates the deacetylation and functional enhancement of PGC-1-a pivotal controller of mitochondrial biosynthesis and cellular antioxidant capacity-while p53 concurrently modulates SLC7A11 expression, a core subunit of the cystine/glutamate antiporter essential for glutathione production (117)

The potential mechanisms by which the microbiota impacts the gut-brain axis and autism progression involve inflammatory and metabolic pathways and alteration of epithelial barrier integrity