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Diabetes upregulates ROS and inflammatory cytokines, which activate PERK/eIF2 and IRE1/XBP1 pathways, aggravating ER dysfunction and apoptotic cell death [129,130,131]

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The purpose of the modeling was to answer questions posed by experiments or experimentalists and to investigate mechanisms of regulation in one-carbon metabolism

Oxidative stress is associated with the pathology of various viral infections, including SARS-CoV-2, IAV, HCV, ZIKV, and HIV infections

Several of the downregulated proteins are centrally implicated in cardiovascular and metabolic pathologies: TNFRSF11B (Osteoprotegerin) has been consistently associated with coronary artery calcification and vascular dysfunction and is known to be upregulated in human vascular smooth muscle cells predisposed to senescence and atherogenesis 6466