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Those who view the transition as a temporary adjustment phase within a long-term weight management journey typically persist through difficulties and achieve good outcomes

The SURMOUNT-5 trial published in the New England Journal of Medicine in May 2025 was the first randomized, head-to-head comparison of the two medications in patients with obesity but without type 2 diabetes

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It is briefly mentioned in the Drug Interactions section to say the drug delays gastric emptying, and may impact absorption of concomitantly administered oral medications. It is also briefly mentioned in the Pharmacodynamics section, which describes how the drug works