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A chemical drug may have a high level of toxicity and low bioavailability, which can cause symptoms such as mouth and throat lesions, nausea, fertility disorders, hair loss, vomiting, fatigue, and even death [53]

Cardiovascular disease is the leading cause of death in the United States, claiming more lives than all forms of cancer combined

Presynaptic cytoplasmic Ca 2+ can be depleted by several complementary mechanisms, including sarcoendoplasmic reticulum Ca 2+ -ATPase (SERCA) to the endoplasmic reticulum (ER), plasma membrane Ca 2+ -ATPase to the extracellular space, and MCU to the mitochondrial matrix [51,52,53]

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