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Genetic polymorphisms in the DIO2 geneparticularly the common Thr92Ala varianthave been associated with altered enzymatic function and reduced intracellular T3 availability in key tissues, despite normal serum TSH and FT4 levels (1416, 29)

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Though the FDA does indicate that healthy adults can typically drink around 400 mg of caffeine per day, equivalent to about 4 or 5 cups of coffee, the agency does not cite a recommended amount of caffeine intake for children and adolescents