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Tirzepatide reduces body weight by increasing fat utilization via the central nervous system-adipose tissue axis in male mice

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Computed circular dichroism spectra for the evaluation of protein conformation

The more weight people regained, the more their health markers slid back towards baseline: Systolic blood pressure rose by 6.8, 7.3, 9.6 and 10.4 mm Hg across the four increasing regain groups Waist circumference crept up by 0.8, 5.4, 10.1 and 14.7 cm Triglycerides and non-HDL cholesterol climbed, especially in those with higher regain Haemoglobin A1c and fasting glucose increased in step with weight regain Insulin resistance (HOMA2-IR) worsened again Participants who kept their weight regain below 25% held on to most of the cardiometabolic improvements, with no significant worsening in waist circumference, some lipid measures and insulin resistance