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Potential side effects include nausea, vomiting, constipation, and injection-site discomfort, particularly during dose escalation

It was first reported 20 years ago that systemic IGFs could cross the bloodbrain barrier (BBB), when labeled IGFs were infused into the common carotid arteries of adult rats, and they were later on detected in the choroid plexus, median eminence, brain arterioles, and parenchyma[64]

Metformin Metformin has been evaluated in numerous small trials in people with type 1 diabetes with hopes that its insulin-sensitising properties would improve glycaemic management and/or reduce cardiovascular risk [244, 245]

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Cost is also a concern