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They are NOT recommended for individuals with: Ulcerative colitis, Crohns disease, or active GI inflammation Severe hemorrhoids Heart arrhythmias or uncontrolled hypertension Pregnancy Kidney disease (electrolyte shifts can be dangerous) Caffeine sensitivity Always consult a licensed provider if you have chronic conditions or are following a detox program

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10.1038/s41586-020-2124-0 126 KandasamyP.GyimesiG.KanaiY.HedigerM