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GDNF supports dopaminergic neurons and plays a role in neural development and repair, but its delivery across the BBB remains a challenge (177)

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Therefore, further investigation is required to determine optimal safe and efficacious doses of the currently clinically available NAD + precursors

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DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain Text PDF Abstract Glucagon-like peptide 1 receptor (GLP-1R) signaling in the CNS has been linked to reduced food intake, lower body weight, improved glucose homeostasis, and activation of CNS stress axes