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Signs and Symptoms of Vitamin B12 Deficiency Vitamin B12 deficiency can lead to various health concerns, including: Fatigue and low energy levels Pale or jaundiced skin Breathlessness or dizziness Pins and needles or numbness Muscle weakness Mood changes, including depression For more information about Vitamin B12 deficiency symptoms, visit the NHS website

A higher expression of IL-4 and IL-13 is uncovered in the synovial fluid of early RA rather than established RA, which means IL-4 and IL-13 would be the diagnostic biomarkers for early RA patients (84, 85)

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