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Unlike single-agent pharmacological therapies, whole foods provide complex mixtures of micronutrients, antioxidants, polyphenols, and bioactive phytochemicals that act on multiple physiological targets (3234)

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stimulates pulsatile GH release without raising cortisol or prolactin Key safety concern / Unknown effects on a still-maturing hypothalamic-pituitary-gonadal axis Guideline position / No endorsement from Endocrine Society, AAP, or AACE for pediatric use Compounding status / Available only through 503A/503B compounders

When looking at complications, the authors separated their analysis aligned with the conceptual distinction between fat mass disease (more prone to mechanical complications) and sick fat disease (more prone to immunological and metabolic complications)