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conducted a systematic review and meta-analysis of four trials involving 800 very low birth weight or very preterm infants to evaluate the effects of low-dose enteral vitamin A supplementation (10,000 IU/day)
ROS stimulate the production of transforming growth factor- (TGF-), a major mediator of fibrosis ( Moreover, oxidative stress disrupts the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), critical for collagen turnover and tissue remodeling ( 3 Therapeutic agents for oxidative stress in TAO and their potential therapeutic targets 3.1 Application of antioxidants TAO exhibits dysregulation of oxidative stress pathways, which can be targeted to mitigate oxidative damage and restore redox balance ( Figure 2 )
A final score of 7 or higher indicates that the study was of high quality (Supplementary Table 1)
Injection site irritation and digestive discomfort are the most reported reactions
This diet is low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP)
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