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Studies from the National Institute of Environmental Health Sciences confirmed that individuals with genetic polymorphisms reducing glutathione S-transferase activity (GSTM1-null and GSTT1-null genotypes, present in 4060% of some populations) showed increased susceptibility to environmental toxins and certain cancers

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Geiser JS, Heathman MA, Cui X, Martin J, Loghin C, Chien JY, de la Pea A (2016) Clinical pharmacokinetics of dulaglutide in patients with type 2 diabetes: analyses of data from clinical trials